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Niasafe-600®

inositol hexaniacinate - a safer, non-flushing alternative to niacin

provides a higher amount of niacin without the flushing

unlike time-release niacin - Niasafe is easy on the liver

supports peripheral vascular circulation

supports lipid metabolism

Niacin has long been used to support good cardiovascular health. It has been proven effective at helping to maintain already normal ...

Niasafe-600®

inositol hexaniacinate - a safer, non-flushing alternative to niacin

provides a higher amount of niacin without the flushing

unlike time-release niacin - Niasafe is easy on the liver

supports peripheral vascular circulation

supports lipid metabolism

Niacin has long been used to support good cardiovascular health. It has been proven effective at helping to maintain already normal levels of cholesterol.

The side effects of high amounts of niacin that may occur range from flushing and itching to liver toxicity and impaired glucose tolerance. Therefore, the need for a safer approach to niacin supplementation resulted in the investigation of niacin esters. One of the most widely studied niacin esters is inositol hexaniacinate (IHN). In numerous trials IHN has been found to be virtually free of the side effects associated with conventional niacin therapy. Pharmacokinetic studies show the IHN molecule is absorbed intact and slowly hydrolyzed in the bloodstream, releasing free niacin and inositol and having a diminished impact on the liver. Maximum serum levels are reached approximately 10 hours after ingestion, thus allowing for a more delayed release of niacin that reduces the risk of flushing.

A review of the literature reveals numerous positive studies on the use of IHN to support good circulatory health, particularly the support of vascular circulation to the extremities.