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For those individuals who prefer a flavored powder that can be mixed with food or beverages, Kirkman® offers Trimethylglycine (TMG) with folic acid and vitamin B-12 in powder form. This product has a pleasant, sweet taste. Our new, improved formulation contains stevia.

Kirkman’s trimethylglycine (TMG) is derived from beets, which is the commercially available source. TMG is dimethylglycine (DMG) with one more methyl group. The ...

For those individuals who prefer a flavored powder that can be mixed with food or beverages, Kirkman® offers Trimethylglycine (TMG) with folic acid and vitamin B-12 in powder form. This product has a pleasant, sweet taste. Our new, improved formulation contains stevia.

Kirkman’s trimethylglycine (TMG) is derived from beets, which is the commercially available source. TMG is dimethylglycine (DMG) with one more methyl group. The chemical structure of TMG is a glycine molecule holding onto three methyl groups. Like DMG, TMG is considered a "methyl donor" or methyl "bank." The additional methyl group makes TMG a more active methyl donor than DMG, which provides a benefit to some individuals. TMG can support the formation of methionine by methylating homocysteine. Some of this methionine eventually is converted into SAMe (S-adenosylmethionine), which can help maintain healthy serotonin levels in the body, thus supporting mood and a feeling of well-being. As with DMG, TMG plus a coenzyme of riboflavin supplies methyl groups that attach to folic acid to form methylene tetrahydrofolate, an important component of many biochemical processes in the body including cellular perception and response.

This Kirkman® formulation also includes folic acid and vitamin B-12. Folic acid intake and levels in the body must be adequate for TMG to work biochemically. As a result, some physicians recommend a TMG supplement containing folic acid. Because folic acid can sometimes mask a vitamin B-12 deficiency, vitamin B-12 has also been included in this formulation. Furthermore, it is known that vitamin B-12 works synergistically with folic acid. The most active form of vitamin B-12 in folate chemistry is methylcobalamin, and Kirkman® utilizes this form of vitamin B-12 in this product, which may assist methionine metabolism, methylation, and folate chemistry. Kirkman