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Folic acid intake and levels in the body must be adequate for TMG to work biochemically. For this reason, some physicians recommend a TMG supplement containing folic acid. Kirkman has such a product containing folic acid. Because folic acid can sometimes mask a B-12 deficiency, vitamin B-12 is included as well.

Basically, Trimethylglycine (TMG) is Dimethylglycine (DMG) with one more methyl group. The chemical structure of TMG is th...

Folic acid intake and levels in the body must be adequate for TMG to work biochemically. For this reason, some physicians recommend a TMG supplement containing folic acid. Kirkman has such a product containing folic acid. Because folic acid can sometimes mask a B-12 deficiency, vitamin B-12 is included as well.

Basically, Trimethylglycine (TMG) is Dimethylglycine (DMG) with one more methyl group. The chemical structure of TMG is therefore is actually a glycine molecule holding onto three methyl groups, so like DMG, TMG is considered a "methyl donor" or methyl "bank". The additional methyl group actually makes TMG a more active methyl donor than DMG which is a benefit in some individuals. TMG can support the formation of methionine by methylating homocysteine. Some of this methionine eventually is converted into SAMe (S-adenosylmthionine), which can help maintain healthy serotonin levels in the body and support mood and well-being. As with DMG, TMG in the body, with the help of a coenzyme of riboflavin, supplies methyl groups which attach to folic acid to form methylene tetrahydrofolate, an important component of many biochemical processes in the body including cellular perception and response.