Nicotinamide riboside (NR) is the most direct precursor to nicotinamide adenine dinucleotide (NAD+). NAD+ is a key component of the citric acid cycle and the electron transport chain, both involved in mitochondrial production of ATP for energy. In addition to its importance in cellular energy production, NAD+ is a critical substrate for several enzymes, including sirtuins (SIRT1 and SIRT3, in particular), which play key roles in healthy aging, weight management, metabolic syndrome, and hepatic lipid metabolism.

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