Alpha-lipoic acid (ALA) has historically been used to mitigate toxic insults to the liver. ALA is also a nutrient cofactor involved in mitochondrial function, thus supporting energy production in the cells. Studies indicate that a higher amount of alpha-lipoic acid – 600-1,800 mg daily – is most effective for neurological support and helping to maintain mental sharpness. Thorne's Alpha-Lipoic Acid provides 300 mg of ALA per capsule. In addition to being an important antioxidant in both fat-soluble and water-soluble tissues, alpha-lipoic acid also helps recycle other antioxidants, including glutathione, another essential antioxidant for liver detoxification.