Biochemically in the body, folic acid supports cellular perception and response, methylation processes and many enzymatic reactions. It is also linked to maintaining healthy homocysteine levels which in turn supports cardiovascular health. To be active in the body, folic acid has to be reduced twice by folate reductase enzymes and is converted to tetrahydrofolate after which a methyl group is added to the tetrahydrofolate. In some individuals, the use of natural folinic acid may be more beneficial than folic acid, because folinic acid already has attached four hydrogen atoms and one methyl group, thereby short cutting the complicated biochemical processes that assist purine and nucleotide synthesis which are so important in cellular perception and response. For that reason, some doctors are recommending folinic acid instead of folic acid supplementation.