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Circadian PM™
A multifaceted approach is needed to support falling asleep faster, staying asleep longer, and achieving higher quality, more restful sleep. Circadian PM™ utilizes a blend of 10 ingredients, promoting multiple mechanisms of action to nurture healthy sleep.
Mechanisms of Action*
-
Promotes a healthy central nervous system & promotes sleep initiation by:
- Increasing GABA, the primary inhibitory central nervous system neurotransmitter*
- Decreasing breakdown of GABA & its binding *
- Stimulating GABA receptor*
- Promotes undisrupted sleep by supporting healthy serotonin levels, leading to increased REM sleep*
- Reduces wakefulness by supporting healthy histamine levels in the brain*
- Supports a healthy response to anxiety, promoting better sleep*
- Promotes normal cytokine function to relax the central nervous system, leading to a healthy pain response*
Complete sleep management with neurotransmitter, cytokine, and histamine support*
The importance of healthy sleep for overall health and well-being cannot be overstated. Unfortunately, achieving quality sleep is a challenge for many people. Common biological contributors to poor sleep can include physical discomfort, stress, anxiety, high histamine levels, and low levels of sleep-promoting neurotransmitters, such as gamma-aminobutyric acid (GABA).[1]
Circadian PM™ features PharmaGABA®, the natural form of GABA, made through a natural fermentation process. This results in a superior form of GABA vs other synthetic options. Synthetic forms of GABA are less bio-available, as their molecular size is too large to pass the blood-brain barrier. PharmaGABA® is easily absorbed and binds to GABA receptors in the peripheral nervous system, activating the parasympathetic nervous system. This activation of the parasympathetic nervous system by PharmaGABA® is measurable within 5 to 30 minutes after ingestion .*
The unique blend of herbs, nutrients, and amino acids make Circadian PM™ a must-have formulation for patients dealing with sleep challenges and those who want to improve the quality of their sleep utilizing natural methods.
| Features | Constituents/Actions | Benefits* |
| CalmNight Blend™ | Glycine, Valerian Extract (Valeriana officinalis) (root), CurcuWIN™ Turmeric Extract, Lemon Balm Extract (Melissa officinalis) (leaf), Magnolia Extract (Magnolia officinalis) (bark), 5 HTP (5-hydroxytryptophan), L-theanine, PharmaGABA® (gamma-aminobutyric acid) | • Supports NREM Stage 1 for sleep initiation* • Nurtures restfulness to help maintain length of time asleep* • Promotes the transition between NREM Stages (1-3), preparing the brain and body for deeper, restorative sleep* • Supports REM, the most important sleep state, allowing the body to repair and restore itself* • Anxiolytic and calming ingredients support GABA levels, as well as serotonin – a precursor to the natural production of melatonin, an essential hormone for quality sleep* • Promotes healthy mental and physical relaxation to reduce wakefulness and restlessness* • Supports normal cytokine function to relax the central nervous system and support physical discomfort* |
| HistaCalm™ | Black Cumin Extract (Nigella sativa) (seed), Stinging Nettle Extract (leaf) | • Promotes a healthy level of histamine to bind to its receptors by competitive inhibition* • Reduces wakefulness by supporting healthy histamine levels in the brain* |
[1] The contributing factors to poor sleep experiences in according to the university students: A cross-sectional study Altun I et al. J Res Med Sci. 2012 Jun; 17(6): 557–561.
Do not use while pregnant or nursing.
Do not use while pregnant or nursing. Non-GMO, vegan. Vegan Manufactured without eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, corn and gluten. Produced in a facility that may process other ingredients containing these allergens.
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Researched Nutritionals: Your Source for Quality Supplements
Researched Nutritionals, founded in 2006, is a trusted provider of research-based dietary supplements. Their mission is to develop formulations supported by clinical trials, catering to the unique needs of healthcare practitioners and their patients.
Top Products by Researched Nutritionals
They offer a range of high-quality supplements, including:
- AnxiaEase: An all-natural stress-relief solution.
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The History and Mission of Researched Nutritionals
Researched Nutritionals® is a trusted provider of research-based dietary supplements. Founded in 2006 by CEO Dennis Schoen, the company's mission is to develop formulations supported by ongoing clinical trials, demonstrating product efficacy. Researched Nutritionals is dedicated to working directly with healthcare practitioners to meet the most challenging patient needs.
Conclusion
Researched Nutritionals is a trusted brand in the practitioner-exclusive dietary supplement market, dedicated to quality and customer satisfaction. Consult with a healthcare practitioner to find the best supplements for your needs.
