Researched Nutritionals - HistaQuel - -
Researched Nutritionals - HistaQuel - -
Researched Nutritionals - HistaQuel - -
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HistaQuel® is a comprehensive formula providing a multi-faceted, systemic approach to supporting healthy mast cell function and histamine response.

Mechanisms of Action

  • Promotes healthy amount of histamine release by supporting healthy mast cell function
  • Supports healthy level of histamine absorption by blocking histamine receptors (via competitive inhibition)

Comprehensive Mast Cell Support*

HistaQuel® is a comprehensive formula providing a multi-faceted, systemic approach to supporting healthy mast cell function and histamine response.*

What is a mast cell?

Mast cells are part of the immune system and are primarily responsible for generating and releasing histamine in the body. Under typical conditions, this is a natural function of a healthy body working to rid itself of an allergen. However, mast cells can become overactive, releasing a cascade of histamine throughout the body, which results in heightened or continuous allergy symptoms.

Many allergy support supplements, such as diamine oxidase (DAO), focus on reducing histamine within the gut by utilizing enzymes to degrade the histamine. Unfortunately, this means they are limited in their function and only effective for reducing ingested histamine (i.e., histamine introduced to the body through the food we eat) within the GI tract. However, mast cells release histamine systemically. Therefore, when mast cells are activated, they release histamine throughout the body. Enzymes such as DAO do nothing to address the healthy function of mast cells or support the body's healthy response to histamine and, therefore, serve limited benefit.

How does HistaQuel® support mast cell health?

HistaQuel® utilizes a comprehensive approach to support healthy mast cell function and histamine response systemically.* Six clinically researched flavonoids and herbs have been combined to promote healthy levels of histamine production and healthy levels of histamine absorption. This holistic approach resulted in a comprehensive formula featuring dual mechanisms of action.*

Dual Mechanisms of Action*

  • Promotes healthy amount of histamine release by supporting healthy mast cell function*
  • Supports healthy level of histamine absorption by blocking histamine receptors (via competitive inhibition)*
Mast Cell Secure™Fisetin, Luteolin, Perilla frutescens, Quercefit® Quercetin Phytosome®•  Targeted flavonoid blend supports a healthy mast cell release of histamine
•  Moderates interactions between mast cells and activated T cells
•  Supports a healthy Th2 release of allergy promoting cytokines IL-4 and IL-5
•  Supports a healthy IgE mediated release of histamine
•  Highly bioavailable form of Quercetin with 20 times increased absorption compared to standard Quercetin in published research
HistaCheck™Stinging Nettle Leaf, Black Cumin (seed) extract•  Promotes a healthy level of histamine to bind to its receptors by competitive inhibition
•  Supports management of a healthy immune system response to allergens

Histamine intolerance can significantly impact daily life, causing a wide range of uncomfortable symptoms from digestive issues to skin problems. Recognizing this challenge, Researched Nutritionals has developed HystaQuel, a supplement designed to help manage histamine levels and support overall well-being. This blog post delves into the features, benefits, and science behind HystaQuel, making it a top choice for those seeking relief from histamine-related issues.

What is HystaQuel?

HystaQuel is a targeted nutritional supplement created by Researched Nutritionals, a brand renowned for its dedication to innovative health solutions backed by scientific research. HystaQuel offers a holistic approach to managing histamine levels in the body, which can be crucial for individuals sensitive to histamine or those with histamine intolerance.

The Science Behind HystaQuel

HystaQuel's effectiveness stems from its unique blend of natural ingredients that synergistically modulate histamine levels and support the body’s natural processes.

Key ingredients include:

  • Quercetin: This potent flavonoid is known for its ability to stabilize mast cells, reducing the release of histamine into the system.
  • Vitamin C: Beyond its well-known immune-boosting effects, Vitamin C also helps degrade histamine, aiding in lowering its levels in the body.
  • Bromelain: As an enzyme, bromelain complements quercetin in supporting the body’s response to inflammation and histamine.

This combination not only helps manage histamine levels but also supports the body's overall immune response and inflammatory processes.

Benefits of HystaQuel

The benefits of HystaQuel are multi-fold. Users often report a significant reduction in symptoms associated with histamine intolerance, such as nasal congestion, hives, and gastrointestinal discomfort. By balancing histamine levels, HystaQuel can help improve quality of life and enhance daily functioning. It is especially beneficial for individuals who struggle with seasonal allergies or those sensitive to dietary histamine.

Quality Assurance

Researched Nutritionals is committed to quality and efficacy across all its products, and HystaQuel is no exception. Manufactured in GMP-certified facilities, each batch of HystaQuel is rigorously tested to ensure purity, potency, and safety. This commitment to quality helps users feel confident in choosing HystaQuel as a reliable solution for managing histamine levels.

Customer Experiences

Positive testimonials from customers who have experienced relief from their symptoms underscore the effectiveness of HystaQuel. These real-life success stories highlight the transformative impact HystaQuel can have on managing histamine-related health issues, further solidifying its reputation as a trusted solution in the nutritional supplements market.


For those dealing with histamine intolerance or seeking to manage their histamine levels more effectively, HystaQuel by Researched Nutritionals offers a scientifically formulated and highly effective solution. Its unique blend of ingredients, commitment to quality, and positive user feedback make it a standout product in the realm of nutritional supplements.

If you’re tired of battling symptoms related to histamine imbalance, consider HystaQuel as your go-to supplement.


As a dietary supplement, take 2 capsules twice per day with or without meals.

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    Promotes healthy amount of histamine release by supporting healthy mast cell function* Supports healthy level of histamine absorption by blocking histamine receptors via competitive inhibition

    Researched Nutritionals: Your Source for Quality Supplements

    Researched Nutritionals, founded in 2006, is a trusted provider of research-based dietary supplements. Their mission is to develop formulations supported by clinical trials, catering to the unique needs of healthcare practitioners and their patients.

    Top Products by Researched Nutritionals

    They offer a range of high-quality supplements, including:

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    5. CoreBiotic® Sensitive: An advanced spore-based probiotic for patients following specific diets.
    6. CytoQuel®: A formula developed to support healthy cytokine function.
    7. HistaQuel®: Comprehensive support for mast cell function and histamine response.
    8. Multi-Biome: A unique probiotic blend supporting a balanced microbiome, histamine levels, and more.
    9. ToxinPul: A versatile binder and detox support formula.
    10. MycoPul®: Targeted binders to remove mycotoxins from the gastrointestinal tract.
    11. Transfer Factor Multi-Immune: An advanced immune support formula.
    12. Tri-Fortify® Liposomal Glutathione: Clinically researched liposomal glutathione for antioxidant support and immune fortification.

    The History and Mission of Researched Nutritionals

    Researched Nutritionals® is a trusted provider of research-based dietary supplements. Founded in 2006 by CEO Dennis Schoen, the company's mission is to develop formulations supported by ongoing clinical trials, demonstrating product efficacy. Researched Nutritionals is dedicated to working directly with healthcare practitioners to meet the most challenging patient needs.


    Researched Nutritionals is a trusted brand in the practitioner-exclusive dietary supplement market, dedicated to quality and customer satisfaction. Consult with a healthcare practitioner to find the best supplements for your needs.