Folic acid, the most common form of folate in supplements and fortified foods, requires the enzyme methylenetetrahydrofolate reductase (MTHFR) to be converted to L-methylfolate, the activated form of folate used by the body for many biochemical reactions. About half of the population have genetic variations that reduce the ability of the MTHFR enzyme to make this conversion. For this population, L-methylfolate supplementation is far more effective in providing this form of folate.
- Supports healthy mood, cardiovascular, and nerve function
- Important for normal production of serotonin, norepinephrine and dopamine
- Essential for converting homocysteine to methionine
What is L-Methylfolate?
Low folate status is one of the most common nutritional deficiencies, and that statistic increases as we age . Not consuming enough folate-rich foods is the primary reason for this deficiency, but many people have interfering health issues that prevent natural folate absorption, and others still are born without the ability to metabolize folic acid properly.
To combat widespread folate deficiency, many food manufacturers began “fortifying” food or adding synthetic folic acid to common foods (white rice, bread, etc.) that don’t naturally contain much folate. One problem with folic acid is that it must be converted to L-methylfolate, the active form of folate, before it can be used by the body for many biochemical reactions. This conversion requires the body to produce an enzyme called methylenetetrahydrofolate reductase (MTHFR). Unfortunately, about half of the population have genetic variations that significantly reduce the ability of the MTHFR enzyme to make this conversion, which means some people cannot make enough active folate to fulfill their physiological needs, no matter how much folic acid they consume . For this population, L-methylfolate supplementation is far more effective in providing sufficient doses of activated folate.
Another problem with synthetic folic acid is that consuming too much may have adverse effects if it builds up, unmetabolized in the bloodstream, especially in the elderly . Folic acid is much slower to break down than natural folate, even in individuals with healthy folate metabolism, and requires the help of the liver and other tissues for activation. Therefore, replacing folic acid supplements with L-methylfolate is a healthy choice for all individuals, regardless of age or genetic predisposition. L-methylfolate completely bypasses the entire folic acid metabolism cycle and has been shown to be more effective than folic acid for increasing circulating active folate in the body .
|Each Serving Contains||Amount per Serving||% of Daily Value|
|from 6.8 mg L-5-methyltetrahydrofolate (5-MTHF)||calcium Salt|
|* Percent of Daily Value Not Established|
Egg free, Gluten free, Nut free, Dairy free