Synergistic Combination of Palmitoylethanolamide (PEA) and Luteolin

• Mirica^® Advanced contains Levagen^®+ PEA with Nearly Twice the Absorption of Standard PEA
• Safe, Effective, Non-Addictive Pain Reducer
• Over 800 published studies and Over 50 Clinical Trials support PEA’s anti-inflammatory, neuroprotective, immune supporting, analgesic properties
• Recommended by Doctors
• Increases Your Body’s Natural Pain Reducing Endocannabinoids
• Clinically studied combination of ingredients has been shown to reduce menstrual discomfort. 
• All Young Nutraceuticals Products are manufactured in the USA under strict Good Manufacturing Practices (cGMP) set by the FDA and are produced with the highest quality ingredients and tested by 3rd party lab for purity and potency
• No artificial ingredients

Mirica® Advanced is made from the highest quality pharmaceutical-grade ingredients available. Mirica® Advanced is made with pure Levagen®+ PEA, clinically shown to have nearly twice the absorption of standard PEA. We believe purity matters, especially when a supplement is a daily part of your life. That's why we never compromise on our ingredients.

Mirica^® is made in a cGMP registered, FDA registered facility in the USA and tested by an independent lab.

Mirica® Advanced's ingredients are naturally sourced, and color variation may occur. This does not impact purity or potency.

Mirica^® Advanced is our enhanced-absorption version of Mirica^®.

It features PEA that has the addition of patented LipiSperse^® technology. LipiSperse^® is essentially a hydrophobic coating for the PEA particles that keeps them dispersed in an aqueous environment, like your stomach. This means the particles are better absorbed by your body, and it has been clinically shown to increase the amount of PEA in your bloodstream by nearly 2X, compared to standard PEA.

Mirica^® Advanced includes the powerful antioxidant polydatin. Polydatin is a naturally occuring precursor of resveratrol. It has the same antioxidant benefits of resveratrol with much higher absorption in the body. It has been clinically studied as a synergistic addition to PEA.* Polydatin has been shown to support the cardiovascular system, and is associated with longevity and its ability to neutralize free radicals.

We've also increased the amount of luteolin in Mirica^® Advanced. This makes Mirica^® Advanced a unique supplement with the same overall benefits of Mirica^®, but with half as many daily capsules!

The Research

In a recent meta-analysis of PEA involving a total of 1484 chronic pain patients, those taking PEA reported pain levels an average of 2.7 points lower than the control groups after 60 days.* (Paladini 2016)

The Synergistic Combination of PEA & Luteolin

When combined, PEA and luteolin show enhanced anti-inflammatory, anti-oxidant and neuroprotective properties. Coadministration of PEA with luteolin has been shown to decrease mast cell activation significantly more than PEA or luteolin alone. This combination has been shown to reduce pro-inflammatory cytokines (TNF-alpha, IL-1 beta, IL-6) and chemokines (MIP-1 alpha, MIP-2) significantly more than PEA or luteolin alone. Additionally, PEA with luteolin was shown to reduce oxidative and nitrosative damage more effectively than PEA or luteolin alone. (Impellizzeri 2018)

Side Effect Free

PEA occurs naturally in the body and in many foods. No side effects have been reported with its use, even at the highest doses. (Gabrielsson 2016)
The recommended daily dose of Mirica^® is equivalent to the amount of luteolin found in one artichoke. At this dose luteolin is safe and no side effects have been reported.

Mirica®'s ingredients are plant-based, and color variation may occur. This does not impact purity or potency.