This fat-soluble form of vitamin B₁ has higher bioavailability compared to water-soluble forms. Benfotiamine inhibits several pathways involved in glucose-induced vascular changes and supports healthy neuron function. Clinical studies show that benfotiamine supports healthy neurological structures and glucose metabolism, limiting the formation of advanced glycation end products (AGEs). Benfotiamine may also be a preferred choice after bariatric surgery as thiamine deficiency is frequently found in these people due to malabsorption.