Omne Diem Histamine Digest supplies Diamine Oxidase (DAO), the enzyme that neutralizes histamine in the digestive tract. Taking Omne Diem Histamine Digest prior to consuming high histamine foods and beverages defends against digestive histamine sensitivity and the occurrence of accompanying reactions.

Natural

Our DAO is a natural enzyme-rich protein extract from porcine kidney that is delivered to the small intestine.

Convenient

DAO promotes histamine degradation within 20 min after intake.

Safe

DAO is not absorbed into the body and no adverse events have been recorded with DAO supplementation.

What is Histamine?

Histamine is a biogenic amine present in our bodies and in our food supply. Biogenic amines are found in everything from dairy products and meats to fruits, vegetables and grains. Processes that result in the microbial alteration of foods — such as aging (meat), fermentation (wine, spirits, cheese), and package processing (prepared packed foods) — can increase the levels of histamine and other biogenic amines in foods and beverages.

Omne Diem™ Histamine Digest supplies Diamine Oxidase, the enzyme that neutralizes dietary histamine in the digestive tract. Taking Omne Diem™ Histamine Digest prior to consuming high histamine foods and beverages defends against digestive histamine sensitivity to help reduce the occurrence of histamine intolerance.

Allergy or Intolerance?

While the symptoms of Histamine Intolerance (HIT) may mimic allergic reactions, HIT is not a classical food allergy. Rather, research suggests that HIT is mediated by a deficiency in levels and/or activity of the Diamine Oxidase enzyme.

Allergy – An immune system response to a specific allergenic substance. Symptoms can appear quickly with very little exposure.

Intolerance – An "allergy-like" reaction that does not involve an immunological response. Reactions can take time to appear and increase upon level of exposure.

Symptoms of Histamine Intolerance

While the symptoms of Histamine Intolerance (HIT) may mimic allergic reactions, HIT is not a classical food allergy. Rather, research suggests that HIT is mediated by a deficiency in levels and/or activity of the Diamine Oxidase enzyme. Reactions are variable, seem unrelated and are widespread. Common reactions include:

• Vasodilation (flushing/reddening)
• Hypotension/Tachycardia
• Stuffy, Runny Nose/Sneezing
• Swelling or Red, Watery Eyes
• Headache or Migraine
• Diarrhea, Cramps, Bloating
• Feelings of Anxiety
• Urticaria (hives)

Prevalence

Solution - Digestive Enzyme: Diamine Oxidase (DAO)*

• Neutralizes histamine in the gut*

• Non-systemic, no drug — nutrient interactions, natural kidney extract

8% of people worldwide are affected by histamine intolerance†

Intolerance occurs when the histamine levels in the body get too high or can’t be broken down properly — when histamine levels exceed the amount of diamine oxidase enzyme (DAO) available for degradation.

Causes of Histamine Intolerance

Imbalance between histamine and the degrading enzyme Diamine Oxidase (DAO)

Histamine-Rich Foods

• Chocolate
• Cheese (all types, especially aged)
• Sauerkraut
• Tuna
• Aged, cured, processed and fermented meats (pepperoni, sausage, bacon)
• Tomatoes/Ketchup
• Vinegar (all types)
• Alcoholic beverages
• Shellfish
• Avocado
• Bananas
• Eggplant

Histamine Liberators

• Berries (especially strawberries)
• Alcoholic Beverages
• Milk and dairy products
• Citrus fruits
• Bananas
• Chocolate
• Shellfish

DAO Enzyme-Inhibiting Drugs

• Acemetacin
• Acetylcysteine
• Adalimumab (Humaira)
• Amitriptyline
• Antihistamines
• Aspirin
• Diazapam
• Duloxetine (Cymbalta)
• Etanercept (Enbrel)
• Fluoxetine (Prozac)
• Haloperidol
• Ibuprofen
• Neomycin
• Propranolol
• Sertraline (Zoloft)
• Venlafaxine
• Verapamil

DOES NOT CONTAIN: Wheat, gluten, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.