Folic acid intake and levels in the body must be adequate for TMG to work biochemically. For this reason, some physicians recommend a TMG supplement containing folic acid in the form of . To be active in the body, folic acid has to be reduced twice by folate reductase enzymes and is converted to tetrahydrofolate after which a methyl group is added to the tetrahydrofolate. In some individuals, the use of natural may be more beneficial than folic acid, because already has attached four hydrogen atoms and one methyl group, thereby short cutting the complicated biochemical processes that assist purine and nucletide synthesis, which are so important in cell perception and response. For that reason, some doctors are recommending TMG with instead of the folic acid form of folate. Kirkman now offers TMG hypoallergenic capsules containing and methyl B-12.

Because folic acid can sometimes mask a B-12 deficiency, vitamin B-12 has been included as well. It is also known that vitamin B-12 works synergistically with folic acid. The most active form of B-12 in folate chemistry is methylcobalamin and Kirkman utilizes this form of B-12 in this product. This new TMG product may better assist methionine metabolism, methylation, and folate chemistry.