Creatine is an amino acid that is involved in energy transfer intracellularly and intercellularly in muscle and brain tissue via the blood stream. It accomplishes this energy transfer by being a phosphate transporter, delivering phosphate to the nucleotide ADP, thus forming the high energy nucleotide ATP which powers cell communication systems. Creatine receives the phosphate from ATP by way of the enzyme activity of creatine kinase. Creatine is produced in the body by a methylation process involving glycine, arginine and S-adenosylmethionine (SAM). Supplementation with the three amino acids, however, does not promote creatine production in the body. If the body is not producing enough creatine, only creatine supplementation or creatine from the diet will restore appropriate body levels. Inadequate body levels of creatine can be present for a number of reasons associated with body biochemistry involving folate, vitamin B-12, methionine, or methylation. Without adequate creatine in the body, muscle and neuronal support can be impaired. Kirkman offers Creatine in 500 mg. Hypoallergenic Capsules. The source is pure creatine monohydrate. No other ingredients are present except for the cellulose in the capsule shell. It is important in choosing a creatine supplement to note its purity and potency. There is a lot of inconsistency in creatine raw materials and labeling of some creatine supplements can be misleading. Kirkman guarantees that only 100% pure creatine monohydrate is used and that the labeled potency is based on the anhydrous creatine value.

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