(A Dipeptidyl peptidase IV (DPP-IV) Analog for Comprehensive Digestion of Protein Peptides) DPP-IV FORTE™ (featuring a Dipeptidyl peptidase IV analog) is one of the most exciting nutritional enzyme supplements available from Kirkman Laboratories. This digestive enzyme can be supplemented alone or in combination with other nutritional enzymes to support the digestive process. This unique enzyme specifically breaks apart proline-containing peptides (casomorphin, gluteomorphin and gliadomorphin), which are generally known to come from dairy products and cereal grains. The DPP-IV enzyme assists digestion of these peptides, which are generally resistant to being completely broken down by other enzymes. WHAT IS DPP-IV? Dipeptidyl peptidase (DPP-IV) is a protein that has multiple functions in the body. It is known under different names depending on where it is found. When DPP-IV is on the surface of the T-cell (lymphocyte), it is called CD26, and supports immune function. When this enzyme is found on and imbedded on the epithelial brush boarder mucosal membrane of the intestinal tract lining it is known as DPP-IV. The importance of DPP-IV is that it has primary function in breaking down casein and side chain activity in breaking down gluten. Thus the use of a DPP-IV containing enzyme will support the digestion of casein-containing milk products as well as the protein in gluten-containing grains.